Molecular basis for the dialysis disequilibrium syndrome: altered aquaporin and urea transporter expression in the brain
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چکیده
منابع مشابه
Molecular basis for the dialysis disequilibrium syndrome: altered aquaporin and urea transporter expression in the brain.
BACKGROUND Cerebral disorders caused by brain oedema characterize the dialysis disequilibrium syndrome, a complication of rapid haemodialysis. Brain oedema is presumably caused by the 'reverse urea effect', i.e. the significant urea gradient between blood and brain after dialysis, with, as a result, an inflow of water into the brain. To assess the molecular basis of this effect, we examined the...
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Dialysis Disequilibrium Syndrome
A aggressive dialysis in a grossly azotemic patient, especially one with severe metabolic acidosis, can lead to dialysis disequilibrium syndrome (DDS). Mild forms present as nausea, vomiting, restlessness, and headache. Severe manifestations include seizures, obtundation, coma, and even death. This clinical picture is caused by cerebral edema induced by one or more of the following mechanisms:
متن کاملSepsis and Dialysis Disequilibrium Syndrome
Dialysis disequilibrium syndrome (DDS) is a central nervous system disorder, usually occurs in patients during hemodialysis (HD) or within 24 hours of HD. DDS was first described by Kennedy et al. in 1962. 11 If a critically ill patient on HD develops severe sepsis and septic shock with multiple organ failure (MOF), the adverse effect of HD on the brain is likely to be amplified, which may pred...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2005
ISSN: 1460-2385,0931-0509
DOI: 10.1093/ndt/gfh877